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Article

Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.

Kidney international - 1 Oct 2009

Ren Shuyu, Babelova Andrea, Moreth Kristin, Xin Cuiyan, Eberhardt Wolfgang, Doller Anke, Pavenstädt Hermann, Schaefer Liliana, Pfeilschifter Josef, Huwiler Andrea

Abstract excerpt

Transforming growth factor-beta2 (TGF-beta2) stimulates the expression of pro-fibrotic connective tissue growth factor (CTGF) during the course of renal disease. Because sphingosine kinase-1 (SK-1) activity is also upregulated by TGF-beta, we studied its effect on CTGF expression and on the devel...

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PMID: 19657322
DOI: 10.1038/ki.2009.297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19657322-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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