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Article

Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop.

Oncotarget - 27 Sept 2016

Zeng Ye, Yao Xinghong, Chen Li, Yan Zhiping, Liu Jingxia, Zhang Yingying, Feng Tang, Wu Jiang, Liu Xiaoheng

Abstract excerpt

Sphingosine-1-phosphate (S1P) induces epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma (HCC). However, its underlying mechanism remains largely unknown. In the present study, we investigated the correlation between S1P and syndecan-1 in HCC, the molecular mechanism involved, as well as their roles in EMT of HCC. Results revealed a high serum S1P level presents in patients with HCC, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27556509
DOI: 10.18632/oncotarget.11450
PMCID: PMC5325366

Genes

HPSE

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