Article
Vaccinia Virus Arrests and Shifts the Cell Cycle.
Viruses - 19 Feb 2022
Martin Caroline K, Samolej Jerzy, Olson Annabel T, Bertoli Cosetta, Wiebe Matthew S, de Bruin Robertus A M, Mercer Jason
Abstract excerpt
Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA damage response. However, the cellular factors and viral effectors that mediate these changes remain unknown. Here, we set out to investigate the effect of VACV...
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