Article
Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus.
Molecular psychiatry - 1 Feb 2004
Corvin A P, Morris D W, McGhee K, Schwaiger S, Scully P, Quinn J, Meagher D, Clair D St, Waddington J L, Gill M
Abstract excerpt
Two recent association studies have implicated the neuregulin-1 gene (NRG1) at chromosome 8p21-22 as a susceptibility gene for schizophrenia. Stefansson et al identified three 'at-risk' haplotypes (HapA, B and C) which spanned the NRG1 locus and shared a common core haplotype. Subsequently, they demonstrated evidence that the core haplotype was associated with schizophrenia in an independent Scottish sample. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.