Article
Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions.
Antimicrobial agents and chemotherapy - 1 Oct 2009
Hirakata Yoichi, Ohmori Kaori, Mikuriya Miwako, Saika Takeshi, Matsuzaki Kaoru, Hasegawa Miyuki, Hatta Masumitsu, Yamamoto Natsuo, Kunishima Hiroyuki, Yano Hisakazu, Kitagawa Miho, Arai Kazuaki, Kawakami Kazuyoshi, Kobayashi Intetsu, Jones Ronald N, Kohno Shigeru, Yamaguchi Keizo, Kaku Mitsuo
Abstract excerpt
Beta-lactamase-negative ampicillin-resistant (BLNAR) isolates of Haemophilus influenzae have been emerging in some countries, including Japan. The Clinical and Laboratory Standards Institute has only a susceptible MIC breakpoint (< or = 1 microg/ml) for piperacillin-tazobactam and a disclaimer comment that BLNAR H. influenzae should be considered resistant, which was adapted without presentation of data. In...
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