Article
Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method.
Antimicrobial agents and chemotherapy - 1 Jul 2008
García-Cobos Silvia, Campos José, Román Federico, Carrera Cristina, Pérez-Vázquez María, Aracil Belén, Oteo Jesús
Abstract excerpt
Ampicillin resistance in Haemophilus influenzae due to alterations in penicillin-binding proteins (beta-lactamase negative ampicillin resistant [BLNAR]) is acquiring increasing clinical and epidemiological importance. BLNAR strains with low ampicillin MICs (0.5 to 4 microg/ml) represent the majority of this population in Europe and the United States, but separating them from susceptible isolates is challenging....
Topics
- Amino Acid Substitution
- Amoxicillin
- Ampicillin Resistance
- Bacterial Proteins
- Disk Diffusion Antimicrobial Tests
- Genes, Bacterial
- Haemophilus Infections
- Haemophilus influenzae
- Humans