Article
The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.
PLoS pathogens - 1 Jul 2009
Maloney Erin, Stankowska Dorota, Zhang Jian, Fol Marek, Cheng Qi-Jian, Lun Shichun, Bishai William R, Rajagopalan Malini, Chatterjee Delphi, Madiraju Murty V
Abstract excerpt
The well-recognized phospholipids (PLs) of Mycobacterium tuberculosis (Mtb) include several acidic species such as phosphatidylglycerol (PG), cardiolipin, phosphatidylinositol and its mannoside derivatives, in addition to a single basic species, phosphatidylethanolamine. Here we demonstrate that an additional basic PL, lysinylated PG (L-PG), is a component of the PLs of Mtb H37Rv and that the lysX gene encoding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.