Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ezrin overexpression in gastrointestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric location.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2009

Wei Yu-Ching, Li Chien-Feng, Yu Shih-Chen, Chou Fong-Fu, Fang Fu-Min, Eng Hock-Liew, Uen Yih-Huei, Tian Yu-Fang, Wu Jing-Mei, Li Shau-Hsuan, Huang Wen-Wei, Li Wei-Ming, Huang Hsuan-Ying

Abstract excerpt

Ezrin, a member of the ezrin-radixin-moesin family, acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-mediated signaling. It implicates tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including pediatric and adult sarcomas. Although ezrin upregulation was shown by cDNA expression profiling, no study has systematically evaluated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colon
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth

Share to Proportional Hazards Models

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Threonine

Share to Tissue Array Analysis

Source

Identifiers

PMID: 19648886
DOI: 10.1038/modpathol.2009.107

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ezrin overexpression in gastrointestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric location.PMID 19648886Read ↗

Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors.Semantic proximity Read ↗

Ezrin's role in gastric cancer progression: Implications for immune microenvironment modulation and therapeutic potentialSemantic proximity Read ↗

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A ReviewSemantic proximity Read ↗

Pathophysiological Roles of Actin-Binding Scaffold Protein, EzrinSemantic proximity Read ↗

Prognostic Stratification of High-risk Gastrointestinal Stromal Tumors in the Era of Targeted TherapySemantic proximity Read ↗

Expression profiling of GIST: CD133 is associated with KIT exon 11 mutations, gastric location and poor prognosis.Semantic proximity Read ↗

Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysisSemantic proximity Read ↗

Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era.Semantic proximity Read ↗

The Janus-faced role of ezrin in "linking" cells to either normal or metastatic phenotype.Semantic proximity Read ↗

Molecular targets for tumour progression in gastrointestinal stromal tumoursSemantic proximity Read ↗

RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.Semantic proximity Read ↗

Ezrin, a key component in tumor metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.