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Article

Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK.

Nuclear medicine and biology - 1 Aug 2009

Vaidyanathan Ganesan, Jestin Emmanuelle, Olafsen Tove, Wu Anna M, Zalutsky Michael R

Abstract excerpt

INTRODUCTION: A 105-kDa double mutant single-chain Fv-Fc fragment (scFv-Fc DM) derived from the anti-p185(HER2) hu4D5v8 antibody (trastuzumab; Herceptin) has been described recently. The goal of this study was to investigate whether improved tumor targeting could be achieved with this fragment through the use of residualizing radioiodination methods. METHODS: The scFv-Fc DM fragment was radioiodinated using...

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Identifiers

PMID: 19647173
DOI: 10.1016/j.nucmedbio.2009.04.002
PMCID: PMC2720881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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