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Article

Trypanosomes have six mitochondrial DNA helicases with one controlling kinetoplast maxicircle replication.

Molecular cell - 28 Aug 2009

Liu Beiyu, Wang Jianyang, Yaffe Nurit, Lindsay Megan E, Zhao Zhixing, Zick Aviad, Shlomai Joseph, Englund Paul T

Abstract excerpt

Kinetoplast DNA (kDNA), the trypanosome mitochondrial DNA, contains thousands of minicircles and dozens of maxicircles interlocked in a giant network. Remarkably, Trypanosoma brucei's genome encodes 8 PIF1-like helicases, 6 of which are mitochondrial. We now show that TbPIF2 is essential for maxicircle replication. Maxicircle abundance is controlled by TbPIF2 level, as RNAi of this helicase caused maxicircle...

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Share to DNA Helicases
Share to DNA, Kinetoplast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Protozoan

Share to DNA Replication

Share to Peptide Hydrolases

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Share to Trypanosoma brucei brucei

Source

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Identifiers

PMID: 19646907
DOI: 10.1016/j.molcel.2009.07.004
PMCID: PMC2763077

Genes

PIF1

Provenance

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