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Article

Incorporating predictor network in penalized regression with application to microarray data.

Biometrics - 1 Jun 2010

Pan Wei, Xie Benhuai, Shen Xiaotong

Abstract excerpt

We consider penalized linear regression, especially for "large p, small n" problems, for which the relationships among predictors are described a priori by a network. A class of motivating examples includes modeling a phenotype through gene expression profiles while accounting for coordinated functioning of genes in the form of biological pathways or networks. To incorporate the prior knowledge of the similar...

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Identifiers

PMID: 19645699
DOI: 10.1111/j.1541-0420.2009.01296.x
PMCID: PMC3338337

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