Article
Optimizing Bayes error for protein structure model selection by stability mutagenesis.
Computational systems bioinformatics. Computational Systems Bioinformatics Conference - 1 Jan 2008
Ye Xiaoduan, Friedman Alan M, Bailey-Kellogg Chris
Abstract excerpt
Site-directed mutagenesis affects protein stability in a manner dependent on the local structural environment of the mutated residue; e.g., a hydrophobic to polar substitution would behave differently in the core vs. on the surface of the protein. Thus site-directed mutagenesis followed by stability measurement enables evaluation of and selection among predicted structure models, based on consistency between...
Topics
- Algorithms
- Bayes Theorem
- Computer Simulation
- Models, Chemical
- Models, Genetic
- Mutagenesis, Site-Directed
- Mutation
- Proteins
- Sequence Analysis, Protein