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Article

A computational framework to empower probabilistic protein design.

Bioinformatics (Oxford, England) - 1 Jul 2008

Fromer Menachem, Yanover Chen

Abstract excerpt

MOTIVATION: The task of engineering a protein to perform a target biological function is known as protein design. A commonly used paradigm casts this functional design problem as a structural one, assuming a fixed backbone. In probabilistic protein design, positional amino acid probabilities are used to create a random library of sequences to be simultaneously screened for biological activity. Clearly, certain...

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Identifiers

PMID: 18586717
DOI: 10.1093/bioinformatics/btn168
PMCID: PMC2718646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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