Article
A computational framework to empower probabilistic protein design.
Bioinformatics (Oxford, England) - 1 Jul 2008
Fromer Menachem, Yanover Chen
Abstract excerpt
MOTIVATION: The task of engineering a protein to perform a target biological function is known as protein design. A commonly used paradigm casts this functional design problem as a structural one, assuming a fixed backbone. In probabilistic protein design, positional amino acid probabilities are used to create a random library of sequences to be simultaneously screened for biological activity. Clearly, certain...
Topics
- Algorithms
- Amino Acid Sequence
- Computer Simulation
- Models, Chemical
- Models, Statistical
- Molecular Sequence Data
- Mutation
- Protein Engineering
- Proteins
- Sequence Analysis, Protein
- Structure-Activity Relationship