Article
Pimitespib is effective on cecal GIST in a mouse model of familial GISTs with KIT-Asp820Tyr mutation through KIT signaling inhibition.
Experimental and molecular pathology - 1 Dec 2021
Kihara Takako, Yuan Jiayin, Watabe Tadashi, Kitajima Kazuhiro, Kimura Neinei, Ohkouchi Mizuka, Hashikura Yuka, Ohkubo Shuichi, Takahashi Tsuyoshi, Hirota Seiichi
Abstract excerpt
Three families with multiple gastrointestinal stromal tumors (GISTs) caused by a germline Asp820Tyr mutation at exon 17 of the c-kit gene (KIT-Asp820Tyr) have been reported. We previously generated a knock-in mouse model of the family, and the mice with KIT-Asp818Tyr corresponding to human KIT-Asp820Tyr showed a cecal tumor equivalent to human GIST. In the model mice, we reported that tyrosine kinase inhibitor,...
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