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Article

Asbestos exposure induces malignant-like phenotypes via minority MOMP and displays characteristics of drug-tolerant persister cells.

Carcinogenesis - 7 Jul 2026

Aggison Jaylon, Medina Cristian, Wu Siqi, Li Naren, Molina-Pelayo Francisco, Ji Jessica, Gergeis Mickael Farouk, Raj Ritika, Xu Yuan, Ripley R Taylor

Abstract excerpt

Pleural mesothelioma usually occurs many years after asbestos fiber exposure; yet the mechanisms that convert chronic damage into malignancy remain unclear. Asbestos fibers induce persistent oxidative and genomic stress that should activate apoptosis via mitochondrial outer membrane permeabilization (MOMP). MOMP normally triggers cytochrome c (cyt c) release as well as mitochondrially derived damage-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42141786
DOI: 10.1093/carcin/bgag030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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