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Article

Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias

2 Jun 2009

Abstract excerpt

Genetic alteration in oral premalignant lesions (OPLs), the precursors of oral squamous cell carcinomas (OSCCs), may represent key changes in disease initiation and development. We ask if DNA amplification occurs at this early stage of cancer development and which oncogenic pathways are disrupted in OPLs. Here, we evaluated 50 high-grade dysplasias and low-grade dysplasias that later progressed to cancer for gene...

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PMID: 19623652
DOI: 10.1002/ijc.24611

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