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Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

23 Jul 2009

Abstract excerpt

Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be the major component of the Lewy body, the mechanisms by which neurons degenerate, as well as basic mechanisms involved in the formation of alpha-synuclein-related inclusions, remain obscure. We have suggested previously that...

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PMID: 19627592
DOI: 10.1186/1750-1326-4-32

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