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LIF-Free Embryonic Stem Cell Culture in Simulated Microgravity

22 Jul 2009

Abstract excerpt

BACKGROUND: Leukemia inhibitory factor (LIF) is an indispensable factor for maintaining mouse embryonic stem (ES) cell pluripotency. A feeder layer and serum are also needed to maintain an undifferentiated state, however, such animal derived materials need to be eliminated for clinical applications. Therefore, a more reliable ES cell culture technique is required. METHODOLOGY/PRINCIPAL FINDINGS: We cultured mouse...

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PMID: 19626124
DOI: 10.1371/journal.pone.0006343

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