Article
Measles viruses of genotype H1 evade recognition by vaccine-induced neutralizing antibodies targeting the linear haemagglutinin noose epitope.
The Journal of general virology - 1 Nov 2009
Finsterbusch Tim, Wolbert Anne, Deitemeier Ingrid, Meyer Kerstin, Mosquera Maria Mar, Mankertz Annette, Santibanez Sabine
Abstract excerpt
The linear haemagglutinin noose epitope (HNE; aa 379-410) is a protective B-cell epitope and considered to be highly conserved in both the vaccine and the wild-type measles virus (MeV) haemagglutinin (H) proteins. Vaccine virus-derived monoclonal antibodies (mAbs) BH6 and BH216, which target the HNE, neutralized MeVs of genotypes B3, C2, D4, D5, D6, D7 and D8, and the vaccine strain Edmonston Zagreb. In the case...
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