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Article

HIV-1 IN alternative molecular recognition of DNA induced by raltegravir resistance mutations.

Journal of molecular recognition : JMR - 1 Jan 2000

Mouscadet Jean-François, Arora Rohit, André Joseph, Lambry Jean-Christophe, Delelis Olivier, Malet Isabelle, Marcelin Anne-Geneviève, Calvez Vincent, Tchertanov Luba

Abstract excerpt

Virologic failure during treatment with raltegravir, the first effective drug targeting HIV integrase, is associated with two exclusive pathways involving either Q148H/R/K, G140S/A or N155H mutations. We carried out a detailed analysis of the molecular and structural effects of these mutations. W...

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Identifiers

PMID: 19623602
DOI: 10.1002/jmr.970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19623602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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