Article
High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009
Chattopadhyay Sujay, Weissman Scott J, Minin Vladimir N, Russo Thomas A, Dykhuizen Daniel E, Sokurenko Evgeni V
Abstract excerpt
Core genes comprising the ubiquitous backbone of bacterial genomes are not subject to frequent horizontal transfer and generally are not thought to contribute to the adaptive evolution of bacterial pathogens. We determined, however, that at least one-third and possibly more than one-half of the c...
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