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Article

Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.

Clinical orthopaedics and related research - 1 Dec 2009

Yoshikawa Hideki, Yoshioka Kiyoko, Nakase Takanobu, Itoh Kazuyuki

Abstract excerpt

The small GTPase Rho and Rho-associated protein kinase (Rho kinase, ROCK) signal participates in a variety of biological functions including vascular contraction, tumor invasion, and penile erection. Evidence also suggests Rho-ROCK is involved in signaling for mesenchymal cellular differentiation. However, whether it is involved in osteoblastic differentiation is unknown. We therefore asked whether Rho-ROCK...

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Identifiers

PMID: 19609629
DOI: 10.1007/s11999-009-0976-6
PMCID: PMC2772944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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