Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.

doi:10.2217/pgs.09.57

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Article

Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.

Pharmacogenomics - 1 Jul 2009

Dorado Pedro, Peñas-LLedó Eva M, de la Rubia Alfredo, LLerena Adrián

Abstract excerpt

AIMS: The CYP2D6 -1584C>G (rs1080985) polymorphism has been identified as another major factor for CYP2D6 function that is possibly associated with ultrarapid metabolism. The mutant -1584G promoter genotype seems to be consistently related to a higher protein expression than -1584C. However, the impact this SNP in the CYP2D6 promoter region has on plasma levels of patients taking CYP2D6 substrates, such as...

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PMID: 19604081
DOI: 10.2217/pgs.09.57

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