Article
Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients.
Nephron. Clinical practice - 1 Jan 2009
Zheng Zhen Lon, Hwang Young-Hwan, Kim Seong Kyun, Kim Sejoong, Son Min Jung, Ro Han, Sung Su-Ah, Lee Hyun Hee, Chung Woo Kyung, Joo Kwon Wook, Yang Jaeseok
Abstract excerpt
BACKGROUND: Hemodialysis patients are prone to ischemic events potentially aggravated by hypoxia. The key player in adaptation to hypoxia is hypoxia-inducible factor-1 alpha (HIF-1alpha). Therefore, we investigated the association of HIF-1alpha polymorphisms with ischemia/hypoxia-related events in hemodialysis patients. METHODS: Patients on maintenance hemodialysis were enrolled from 4 training hospitals in...
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