Article
Length polymorphism in heme oxygenase-1 is associated with arteriovenous fistula patency in hemodialysis patients.
Kidney international - 1 Jan 2006
Lin C-C, Yang W-C, Lin S-J, Chen T-W, Lee W-S, Chang C-F, Lee P-C, Lee S-D, Su T-S, Fann C S-J, Chung M-Y
Abstract excerpt
Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme degradation, producing carbon monoxide (CO), which carries potent antiproliferative and anti-inflammatory effects in the vascular walls. Transcription of the HO-1 gene is regulated by the length polymorphism of dinucleotide guanosine thymine repeat (GT)(n) in the promoter region, which was measured in this study to determine its association with...
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