Article
No association between CYP2D6*10 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment.
Japanese journal of clinical oncology - 1 Oct 2009
Toyama Tatsuya, Yamashita Hiroko, Sugiura Hiroshi, Kondo Naoto, Iwase Hirotaka, Fujii Yoshitaka
Abstract excerpt
OBJECTIVE: The CYP2D6 enzyme plays a major role in converting tamoxifen to its active metabolites. We investigated whether there is an association between the CYP2D6*10 allele and clinical outcome in node-negative Japanese breast cancer patients. METHODS: CYP2D6 genotyping was performed in 154 node-negative breast cancer patients who had received adjuvant tamoxifen treatment alone. The CYP2D6 genotypes were...
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