Signaling network analysis of ubiquitin-mediated proteins suggests correlations between the 26S proteasome and tumor progression

Abstract excerpt

We performed a comprehensive analysis of a literature-mined human signaling network by integrating data on ubiquitin-mediated protein half-lives. We found that proteins with very long half-lives are connected to form a network backbone, while proteins with short and medium half-lives preferentially attach to the network backbone and scatter throughout the network. Furthermore, proteins with short and medium...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Peptidase Inhibition and Analysis
• Share to RNA modifications and cancer
• Share to Ubiquitin and proteasome pathways