Article
Apoptosis regulators and their role in tumorigenesis.
Biochimica et biophysica acta - 1 Oct 2001
Zörnig M, Hueber A, Baum W, Evan G
Abstract excerpt
It has become clear that, together with deregulated growth, inhibition of programmed cell death (PCD) plays a pivotal role in tumorigenesis. In this review, we present an overview of the genes and mechanisms involved in PCD. We then summarize the evidence that impaired PCD is a prerequisite for tumorigenesis, as indicated by the fact that more and more neoplastic mutations appear to act by interfering with PCD....
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