Article
Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro.
Hepatology (Baltimore, Md.) - 1 Sept 2009
March Sandra, Hui Elliot E, Underhill Gregory H, Khetani Salman, Bhatia Sangeeta N
Abstract excerpt
UNLABELLED: Liver sinusoidal endothelial cells (LSECs) differ, both structurally and functionally, from endothelial cells (ECs) lining blood vessels of other tissues. For example, in contrast to other ECs, LSECs possess fenestrations, have low detectable levels of platelet endothelial cell adhesion molecule 1 expression, and in rat tissue, they distinctively express a cell surface marker recognized by the SE-1...
Topics
- Animals
- Cell Survival
- Cells, Cultured
- Coculture Techniques
- Endothelial Cells
- Environment
- Extracellular Matrix
- Humans
- Liver
- Mice
- Phenotype
- Platelet Endothelial Cell Adhesion Molecule-1