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Article

Attenuation of proteolysis‐mediated cyclin E regulation by alternatively spliced <i>Parkin</i> in human colorectal cancers

11 May 2009

Abstract excerpt

Parkin has a critical role in the ubiquitin-proteasome system as an E3-ligase targeting several substrates. Our recent finding that Parkin-deficient mice are susceptible to tumorigenesis provided evidence that Parkin is a tumor suppressor gene. Dysfunction of the Parkin gene is frequently observed in various human cancers, but the mechanism underlying the cell cycle disruption induced by Parkin dysfunction that...

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PMID: 19585504
DOI: 10.1002/ijc.24565

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