Article
Parkin as a tumor suppressor gene for hepatocellular carcinoma.
Oncogene - 9 Oct 2008
Fujiwara M, Marusawa H, Wang H-Q, Iwai A, Ikeuchi K, Imai Y, Kataoka A, Nukina N, Takahashi R, Chiba T
Abstract excerpt
The parkin was first identified as a gene implicated in autosomal recessive juvenile Parkinsonism. Deregulation of the parkin gene, however, has been observed in various human cancers, suggesting that the parkin gene may be important in tumorigenesis. To gain insight into the physiologic role of parkin, we generated parkin-/- mice lacking exon 3 of the parkin gene. We demonstrated here that parkin-/- mice had...
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