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Article

Influence of the level of cytosolic epoxide hydrolase on the induction of sister chromatid exchanges by trans-beta-ethylstyrene 7,8-oxide in human lymphocytes.

Biochemical pharmacology - 6 Nov 1991

Krämer A, Frank H, Setiabudi F, Oesch F, Glatt H

Abstract excerpt

trans-beta-Ethylstyrene 7,8-oxide, a substrate of cytosolic epoxide hydrolase, and 4-fluorochalcone oxide, an inhibitor of this enzyme, were investigated on induction of sister chromatid exchanges (SCE) in human lymphocytes. Both epoxides enhanced the frequency of SCE. 4-Fluorochalcone oxide at low concentration (2.5 microM) inhibited cytosolic epoxide hydrolase activity towards trans-beta-ethylstyrene 7,8-oxide...

Topics

Cells, Cultured
Chalcone
Chalcones
Cytosol
Epoxide Hydrolases
Genetic Variation
Glutathione
Humans
Inactivation, Metabolic
Kinetics
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sister Chromatid Exchange

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Identifiers

PMID: 1958232
DOI: 10.1016/0006-2952(91)90350-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1958232-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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