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p53 codon 72 polymorphism and risk of cervical carcinoma in Korean women.

Journal of Korean medical science - 1 Feb 2000

Baek W K, Cho J W, Suh S I, Suh M H, Shin D H, Cho C H, Lee T S, Cha S D

Abstract excerpt

A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro). A recent study suggested that this polymorphism affects the susceptibility of p53 protein to human papillomavirus E6 oncoprotein mediated degradation and that individuals homozygous for p53Arg are seven times more susceptible to HPV-associated carcinogenesis of...

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Identifiers

PMID: 10719811
DOI: 10.3346/jkms.2000.15.1.65
PMCID: PMC3054593

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