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Article

Monitoring Therapeutic Efficacy by Real-Time Detection of Mycobacterium tuberculosis mRNA in Sputum

2 Jul 2009

Abstract excerpt

BACKGROUND: Current laboratory methods for monitoring the response to therapy for tuberculosis (TB) rely on mycobacterial culture. Their clinical usefulness is therefore limited by the slow growth rate of Mycobacterium tuberculosis. Rapid methods to reliably quantify the response to anti-TB drugs are desirable. METHODS: We developed 2 real-time PCR assays that use hydrolysis probes to target DNA of the IS6110...

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Identifiers

PMID: 19574468
DOI: 10.1373/clinchem.2009.124396

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