Article
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2004
De Gendt Karel, Swinnen Johannes V, Saunders Philippa T K, Schoonjans Luc, Dewerchin Mieke, Devos Ann, Tan Karen, Atanassova Nina, Claessens Frank, Lécureuil Charlotte, Heyns Walter, Carmeliet Peter, Guillou Florian, Sharpe Richard M, Verhoeven Guido
Abstract excerpt
Androgens control spermatogenesis, but germ cells themselves do not express a functional androgen receptor (AR). Androgen regulation is thought to be mediated by Sertoli and peritubular myoid cells, but their relative roles and the mechanisms involved remain largely unknown. Using Cre/loxP technology, we have generated mice with a ubiquitous knockout of the AR as well as mice with a selective AR knockout in...
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