Article
Association study and mutation analysis of adiponectin shows association of variants in APM1 with complex obesity in women.
Annals of human genetics - 1 Sept 2009
Beckers Sigri, Peeters Armand V, de Freitas Fenna, Mertens Ilse L, Verhulst Stijn L, Haentjens Dominique, Desager Kristine N, Van Gaal Luc F, Van Hul Wim
Abstract excerpt
We performed an association study and mutation analysis of the adiponectin (APM1) gene to study its involvement in the development of obesity. We also studied the interaction with peroxisome proliferator-activated receptor gamma (PPARgamma). 223 obese women and 87 healthy female control subjects were used for association analysis. Mutation analysis was done on 95 morbidly obese adults and 123 overweight and obese...
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