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Article

Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.

European child & adolescent psychiatry - 1 Jan 2010

Freitag Christine M, Agelopoulos Konstantin, Huy Ellen, Rothermundt Matthias, Krakowitzky Petra, Meyer Jobst, Deckert Jürgen, von Gontard Alexander, Hohoff Christa

Abstract excerpt

Autism spectrum disorders (ASDs) are heterogeneous disorders presenting with increased rates of anxiety. The adenosine A(2A) receptor gene (ADORA2A) is associated with panic disorder and is located on chromosome 22q11.23. Its gene product, the adenosine A(2A) receptor, is strongly expressed in the caudate nucleus, which also is involved in ASD. As autistic symptoms are increased in individuals with 22q11.2...

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PMID: 19565319
DOI: 10.1007/s00787-009-0043-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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