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Article

Regulation of matrix contraction in chronic venous disease.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery - 1 Oct 2009

Pappas P J, Lal B K, Ohara N, Saito S, Zapiach L, Durán W N

Abstract excerpt

OBJECTIVE: The role of TGF-beta(1) in venous ulcer healing and the signalling cascades regulating dermal fibroblast function are poorly understood. To elucidate these processes, we hypothesized that TGF-beta(1) facilitates wound healing by increasing chronic venous insufficiency (CVI) induced matrix contraction via intracellular cross-talk between TGF-beta(1) and the ERK-1/2 MAP kinase signalling cascades....

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Identifiers

PMID: 19560950
DOI: 10.1016/j.ejvs.2009.05.012
PMCID: PMC4004365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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