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Article

Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus.

Journal of general microbiology - 1 Jul 1991

Bascarán V, Sánchez L, Hardisson C, Braña A F

Abstract excerpt

Cephalosporin biosynthetic activity and extracellular protease production increased during growth of Streptomyces clavuligerus in defined medium, while the level of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) remained very low and stable. Cephalosporin biosynthesis (measured in resting cell systems) was initiated during early exponential growth in complex media, without appreciable change in the small ppGpp...

Topics

Amino Acids
Ammonia
Cephalosporins
Culture Media
Drug Resistance, Microbial
Endopeptidases
Glutamine
Guanosine Tetraphosphate
Kinetics
Lysine
Mutation
Streptomyces

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Source

Identifiers

PMID: 1955856
DOI: 10.1099/00221287-137-7-1625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1955856-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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