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Article

Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2009

Eguchi Takashi, Maruyama Tatsuya, Ohno Yoichi, Morii Toshiyuki, Hirao Keiichi, Hirose Hiroshi, Kawabe Hiroshi, Saito Ikuo, Hayashi Matsuhiko, Saruta Takao

Abstract excerpt

The tumor necrosis factor (TNF)-alpha pathway has a key role in regulating insulin resistance. TNF receptor 2 (TNFR2) is an emerging candidate gene for insulin resistance in essential hypertension. We examined the association of insulin resistance and enhanced TNF pathway with severe hypertension...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19557004
DOI: 10.1038/hr.2009.91

Genes

TNF
CRP
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19557004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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