Article
Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2009
Eguchi Takashi, Maruyama Tatsuya, Ohno Yoichi, Morii Toshiyuki, Hirao Keiichi, Hirose Hiroshi, Kawabe Hiroshi, Saito Ikuo, Hayashi Matsuhiko, Saruta Takao
Abstract excerpt
The tumor necrosis factor (TNF)-alpha pathway has a key role in regulating insulin resistance. TNF receptor 2 (TNFR2) is an emerging candidate gene for insulin resistance in essential hypertension. We examined the association of insulin resistance and enhanced TNF pathway with severe hypertension and the association of a microsatellite polymorphism of the TNFR2 gene with severe hypertension. Male severe essential...
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