Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations.

doi:10.5551/jat.e599

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Article

Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations.

Journal of atherosclerosis and thrombosis - 1 Jun 2009

Koseki Masahiro, Matsuyama Akifumi, Nakatani Kazuhiro, Inagaki Miwako, Nakaoka Hajime, Kawase Ryota, Yuasa-Kawase Miyako, Tsubakio-Yamamoto Kazumi, Masuda Daisaku, Sandoval Jose C, Ohama Tohru, Nakagawa-Toyama Yumiko, Matsuura Fumihiko, Nishida Makoto, Ishigami Masato, Hirano Ken-ichi, Sakane Naoki, Kumon Yoshitaka, Suehiro Tadashi, Nakamura Tadashi, Shimomura Iichiro, Yamashita Shizuya

Abstract excerpt

AIM: Tangier disease (TD), caused by deficiency of ATP-binding cassette transporter A1, is characterized by the absence of high density lipoprotein and the accumulation of cholesteryl esters in many tissues. Recently, it has been reported that ABCA1 is expressed in pancreatic beta cells and mice with specific inactivation of ABCA1 in beta cells showed markedly impaired insulin secretion, suggesting that ABCA1...

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Identifiers

PMID: 19556721
DOI: 10.5551/jat.e599

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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