Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.

doi:10.2337/dc22-2078

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Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.

Diabetes care - 1 May 2023

Andersen Mette K, Ängquist Lars, Bork-Jensen Jette, Jonsson Anna E, Stinson Sara E, Sandholt Camilla H, Thodberg Malte, Pikkupeura Laura Maarit, Ongstad Emily L, Grarup Niels, Astrup Arne, Pedersen Oluf, Williams Kristine, Barrès Romain, Sørensen Thorkild I A, Linneberg Allan, Grimsby Joseph, Rhodes Christopher J, Hansen Torben

Abstract excerpt

OBJECTIVE: The association between FTO rs9939609 and obesity is modified by physical activity (PA) and/or insulin sensitivity (IS). We aimed to assess whether these modifications are independent, to assess whether PA and/or IS modify the association between rs9939609 and cardiometabolic traits, and to elucidate underlying mechanisms. RESEARCH DESIGN AND METHODS: Genetic association analyses comprised up to 19,585...

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Alpha-Ketoglutarate-Dependent Dioxygenase FTO

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Body Mass Index

Cardiovascular Diseases

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PMID: 36809463
DOI: 10.2337/dc22-2078

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Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.PMID 36809463Read ↗

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