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Article

The bactericidal effect of a complement-independent antibody is osmolytic and specific to Borrelia.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009

LaRocca Timothy J, Holthausen David J, Hsieh Chyongere, Renken Christian, Mannella Carmen A, Benach Jorge L

Abstract excerpt

A complement-independent bactericidal IgG1 against the OspB of Borrelia burgdorferi increased the permeability of the outer membrane through the creation of openings of 2.8 - 4.4 nm, resulting in its osmotic lysis. Cryo-electron microscopy and tomography demonstrated that exposure to the antibody causes the formation of outer membrane projections and large breaks which may precede the increase in permeability of...

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Source

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Identifiers

PMID: 19549817
DOI: 10.1073/pnas.0901858106
PMCID: PMC2705580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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