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Article

The Complement Binding and Inhibitory Protein CbiA of Borrelia miyamotoi Degrades Extracellular Matrix Components by Interacting with Plasmin(ogen).

Frontiers in cellular and infection microbiology - 1 Jan 2018

Nguyen Ngoc T T, Röttgerding Florian, Devraj Gayatri, Lin Yi-Pin, Koenigs Arno, Kraiczy Peter

Abstract excerpt

The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spirochetes resistant to complement-mediated lysis. To gain deeper insight into the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29456970
DOI: 10.3389/fcimb.2018.00023
PMCID: PMC5801413

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