Article
Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo.
PLoS genetics - 1 Jun 2009
Ren Yunqing, Yang Sen, Xu Shengxin, Gao Min, Huang Wei, Gao Tianwen, Fang Qiaoyun, Quan Cheng, Zhang Chi, Sun Liangdan, Liang Yanhua, Han Jianwen, Wang Zhimin, Zhang Fengyu, Zhou Youwen, Liu Jianjun, Zhang Xuejun
Abstract excerpt
Our previous genome-wide linkage analysis identified a susceptibility locus for generalized vitiligo on 22q12. To search for susceptibility genes within the locus, we investigated a biological candidate gene, X-box binding protein 1(XBP1). First, we sequenced all the exons, exon-intron boundaries as well as some 5' and 3' flanking sequences of XBP1 in 319 cases and 294 controls of Chinese Hans. Of the 8 common...
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