Article
Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis.
PLoS genetics - 1 Jun 2009
Zinovieva Elena, Bourgain Catherine, Kadi Amir, Letourneur Franck, Izac Brigitte, Said-Nahal Roula, Lebrun Nicolas, Cagnard Nicolas, Vigier Agathe, Jacques Sébastien, Miceli-Richard Corinne, Garchon Henri-Jean, Heath Simon, Charon Céline, Bacq Delphine, Boland Anne, Zelenika Diana, Chiocchia Gilles, Breban Maxime
Abstract excerpt
Spondyloarthritis (SpA) is a chronic inflammatory disorder with a strong genetic predisposition dominated by the role of HLA-B27. However, the contribution of other genes to the disease susceptibility has been clearly demonstrated. We previously reported significant evidence of linkage of SpA to chromosome 9q31-34. The current study aimed to characterize this locus, named SPA2. First, we performed a fine linkage...
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