Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular immune response to cryptic epitopes during therapeutic gene transfer

16 Jun 2009

Abstract excerpt

The immune response has been implicated as a critical factor in determining the success or failure of clinical gene therapy trials. Generally, such a response is elicited by the desired transgene product or, in some cases, the delivery system. In the current study, we report the previously uncharacterized finding that a therapeutic cassette currently being used for human investigation displays alternative reading...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19541644
DOI: 10.1073/pnas.0902269106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular immune response to cryptic epitopes during therapeutic gene transferPMID 19541644Read ↗

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transferSemantic proximity Read ↗

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transferSemantic proximity Read ↗

Translational Potential of Immune Tolerance Induction by AAV Liver-Directed Factor VIII Gene Therapy for Hemophilia ASemantic proximity Read ↗

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectorsSemantic proximity Read ↗

A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy.Semantic proximity Read ↗

Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia BSemantic proximity Read ↗

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cellsSemantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody ResponsesSemantic proximity Read ↗

CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.Semantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

Role of Vector in Activation of T Cell Subsets in Immune Responses against the Secreted Transgene Product Factor IXSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.