Article

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

2003-05-01

Abstract excerpt

Gene replacement therapy is an attractive approach for treatment of genetic disease, but may be complicated by the risk of a neutralizing immune response to the therapeutic gene product. There are examples of humoral and cellular immune responses against the transgene product as well as absence of such responses, depending on vector design and the underlying mutation in the dysfunctional gene. It has been unclear,...

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Literature Corpus work: 4b5aa89d-8bad-5d1d-a02f-ef7ad32d83c7
DOI: 10.1172/jci200316887

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