Article
Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure.
Clinical pharmacology and therapeutics - 1 Mar 2019
Saiz-Rodríguez Miriam, Romero-Palacián Daniel, Villalobos-Vilda Carlos, Caniego José Luis, Belmonte Carmen, Koller Dora, Bárcena Eduardo, Talegón María, Abad-Santos Francisco
Abstract excerpt
This observational retrospective study assessed the antiplatelet response and clinical events after clopidogrel treatment in patients who underwent percutaneous neurointervention, related to CYP2C19 metabolizer status (normal (NM), intermediate/poor (IM-PM), and ultrarapid (UM); inferred from *2, *3, and *17 allele determination). From 123 patients, IM-PM had a higher aggregation value (201.1 vs. 137.6 NM, 149.4...
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