Article
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009
Gerasimenko Julia V, Lur György, Sherwood Mark W, Ebisui Etsuko, Tepikin Alexei V, Mikoshiba Katsuhiko, Gerasimenko Oleg V, Petersen Ole H
Abstract excerpt
Toxic alcohol effects on pancreatic acinar cells, causing the often fatal human disease acute pancreatitis, are principally mediated by fatty acid ethyl esters (non-oxidative products of alcohol and fatty acids), emptying internal stores of Ca(2+). This excessive Ca(2+) liberation induces Ca(2+)-dependent necrosis due to intracellular trypsin activation. Our aim was to identify the specific source of the Ca(2+)...
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